Determination of HNP and pKa Values of Some 3-Alkyl(Aryl)-4-phthalimido-4,5-dihydro-1H-1,2,4-triazol-5-one Compounds by Semi-Neutralization Method
نویسندگان
چکیده
In this study, the effects of solvents and molecular structure upon acidity, five 3-alkyl(aryl)-4-phthalimido-4,5-dihydro-1H-1,2,4-triazol-5-ones (3-7) were potentiometrically titrated with tetrabutylammonium hydroxide (TBAH) in four different anhydrous (isopropyl alcohol, acetonitrile, tert-butyl alcohol N,N-dimethylformamide) HNP corresponding pKa values determined by half-neutralization method for all cases.
منابع مشابه
Synthesis and determination of pKa values of some new 3,4-disubstituted-4,5-dihydro-1H-1,2,4-triazol-5-one derivatives in non-aqueous solvents.
3-Alkyl(Aryl)-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones (2) reacted with 2-furoyl chloride and thiophene-2-carbonyl chloride to afford the corresponding 3- alkyl(aryl)-4-(2-furoylamino)-4,5-dihydro-1H-1,2,4-triazol-5-ones (3) and 3-alkyl(aryl)- 4-(2-thienylcarbonylamino)-4,5-dihydro-1H-1,2,4-triazol-5-ones (4), respectively. The new compounds synthesized were characterized by using IR, 1H-NMR...
متن کامل3-{4-[(4-Methoxybenzylidene)amino]-3-phenyl-5-sulfanylidene-4,5-dihydro-1H-1,2,4-triazol-1-yl}-1,3-diphenylpropan-1-one
In the title mol-ecule, C(31)H(26)N(4)O(2)S, the phenyl ring attached to the 1,2,4-triazole ring forms dihedral angles of 65.4 (2), 63.4 (2) and 62.2 (2)° with the other three rings. The 1,2,4-triazole ring makes dihedral angles of 78.0 (2), 87.9 (2), 24.9 (2) and 62.8 (2)° with three phenyl rings and the methoxyphenyl ring.
متن کامل5-(4-Fluorophenyl)-3-[5-methyl-1-(4-methylphenyl)-1H-1,2,3-triazol-4-yl]-4,5-dihydro-1H-pyrazole-1-carbothioamide
In the title compound, C(20)H(19)FN(6)S, the pyrazole ring has an envelope conformation, with the methine C atom being the flap atom. The dihedral angle between the least-squares plane through the pyrazole and triazole rings is 7.59 (9)°, and the triazole and attached benzene ring form a dihedral angle of 74.79 (9)°. The thio-urea group is coplanar with the pyrazole ring [N-N-C-S torsion angle ...
متن کامل3-[3-Methyl-4-(3-nitrobenzylideneamino)-5-sulfanylidene-4,5-dihydro-1H-1,2,4-triazol-1-yl]-1,3-diphenylpropan-1-one
In the title mol-ecule, C(25)H(21)N(5)O(3)S, the triazole ring forms dihedral angles of 21.4 (2), 61.4 (2) and 102.4 (2)° with the nitro-phenyl and two phenyl rings, respectively. In the crystal, weak C-H⋯O hydrogen bonds and π-π inter-actions between the benzene rings from neighbouring mol-ecules [with a centroid-centroid distance of 3.571 (3) Å] consolidate the crystal packing.
متن کاملSynthesis and non-aqueous medium titrations of some new 4-benzylidenamino-4,5-dihydro-1H-1,2,4-triazol-5-one derivatives.
The synthesis of 3-alkyl(aryl)-4-(3-ethoxy-4-hydroxybenzylidenamino)-4,5-dihydro-1H-1,2,4-triazol-5-ones 3 from the reactions of 3-alkyl(aryl)-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones 2 with 3-ethoxy-4-hydroxybenzaldehyde is described. The acetylation and methylation reactions of the compounds 3 giving compounds of type 4 and 5, respectively, were investigated. The newly synthesized compound...
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ژورنال
عنوان ژورنال: Caucasian journal of science
سال: 2022
ISSN: ['2148-6840']
DOI: https://doi.org/10.48138/cjo.1200631